Mama Said Come on Out

Will Basson come out on top?

sofosbuvir has come out of the magic box

Get out! And don't come back!

sing the immune system to attack cancers is a good idea, but it may only work if Toll-like receptors (TLRs) are activated to break tolerance, say Yiping Yang (Duke University, Durham, NC), Drew Pardoll (Johns Hopkins, Baltimore, MD), and colleagues. The favored method for delivering cancer immunotherapy has been dendritic cells: they are the central antigen-presenting cells for generating T cel...

Sorting out where fibroblasts come from.

H eart failure is the primary cause of adult mortality in the Western world, affecting 1% to 2% of the population, including ≤10% of people >70 1. Several disease settings, including coronary artery disease, hypertension, diabetes melli-tus, and hypertrophic cardiomyopathy, promote a maladaptive response characterized by myocyte hypertrophy and fibrosis. The latter refers to excessive extracell...

Has It Come Out of Its Marginality?

This paper explores the role migration has played in development studies, and in debates on economic growth and poverty. It argues that, despite a recent surge of interest in international migration and remittances, research on human mobility particularly for labour within poor countries does not have the place it deserves, and that it used to have in the classical development literature. Revie...